The pesticide dichlorvos disrupts mitotic division by delocalizing the kinesin Kif2a from centrosomes
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چکیده
منابع مشابه
Nucleation of microtubules from mitotic centrosomes
At the onset of mitosis a class of proteins appears that possess a phosphorylated epitope recognized by the monoclonal antibody MPM-2. Immunofluorescence staining shows that a subset of these proteins is associated with the centrosomes of the mitotic apparatus. The appearance of these proteins coincides with the increased microtubule nucleating capacity of the centrosomes. We have tested whethe...
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We identified the mitotic kinesin-like protein 2 (MKlp2), a kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis, as a target of the mitotic checkpoint protein Mad2. MKlp2 possesses a consensus Mad2-binding motif required for Mad2 binding. Mad2 prevents MKlp2 from loading onto the mitotic spindle, a prerequisite step for its function as a mitotic kinesin. Furthermore, Ma...
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ژورنال
عنوان ژورنال: Environmental and Molecular Mutagenesis
سال: 2013
ISSN: 0893-6692
DOI: 10.1002/em.21769